Free energy of conformational transition paths in biomolecules: The string method and its application to myosin VI
Population
Converter domain of myosin VI (computational model)
Authors
Discussion
Loading...
Member takes
Implication
Details myosin VI transitions via simulation; extends biophysical tools but leaves clinical translation open.
Structured PICO
P
Population
Converter domain of myosin VI (computational model)
I
Intervention
String method combined with all-atom molecular dynamics simulations
O
Outcome
Free energy profiles and rates of interconversion along the transition path between prepowerstroke and rigor structures
The study demonstrates the utility of the string method combined with molecular dynamics simulations for analyzing complex conformational transitions in large biomolecules like myosin VI.
Cite This Study
Ovchinnikov et al. (2011) studied this question.