Caged but not trapped! Caged reagents are molecules from which biological effectors are released by photolysis. Here, p-hydroxyphenacyl bromide is used to derivatize a model peptide containing a thiophosphotyrosine residue in order to mimic phosphorylation at tyrosine. Upon photolysis, a biologically active peptide is released. Peptides and proteins caged on thiophosphotyrosine will be useful in signal transduction research.
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Zou et al. (2001) studied this question.
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