Key result
NTS kainic acid injection induces hypertension alongside a ~12-fold increase in spinal cord Fos-IR nuclei.
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Kainic acid injected into rat nucleus tractus solitarius (NTS) caused a slowly developing hypertension, with a 2-fold increase in Fos-immunoreactive (Fos-IR) nuclei in the area of the presympathetic bulbospinal neurons in the rostral ventrolateral medulla (RVLM) and a widespread activation of sympathetic preganglionic neurons (SPN) in the spinal cord, particularly in the mid to lower thoracic cord. The highest segmental concentration of Fos-IR SPN was in T8, with Fos-IR nuclei increased 12-fold compared with the vehicle injected group. More than 60% of retrogradely labelled sympathoadrenal neurons in T8 were Fos-IR after kainic acid injection, consistent with the 60-fold increases in plasma adrenaline levels observed in these rats.
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Minson et al. (1992) studied Hypertension (rat model). Kainic acid injection into the nucleus tractus solitarius (NTS) vs. Vehicle injection was evaluated on Hypertension and Fos-immunoreactive (Fos-IR) nuclei expression in the RVLM and spinal cord. Kainic acid injection into rat NTS evoked hypertension, a 12-fold increase in T8 spinal cord Fos-IR nuclei vs vehicle, and a 60-fold rise in plasma adrenaline.
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