What question did this study set out to answer?

To determine the expression patterns and biological relevance of FGF7, FGF10, and FGFR2 signaling in lung tissue remodeling associated with IPF and IPAH.

May 3, 2018AJP Lung Cellular and Molecular PhysiologyOpen Access

Is the fibroblast growth factor signaling pathway a victim of receptor tyrosine kinase inhibition in pulmonary parenchymal and vascular remodeling?

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Authors

EAElie El AghaJustus-Liebig-Universität Gießen FSFelix SchwindJustus-Liebig-Universität Gießen CRClemens RuppertJustus-Liebig-Universität Gießen

Discussion

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Implication

Translational study demonstrates protective FGF7, FGF10, and FGFR2 upregulation in IPF and IPAH lungs, suggesting broad kinase inhibitors may hinder natural pulmonary repair mechanisms.

Key Points

To determine the expression patterns and biological relevance of FGF7, FGF10, and FGFR2 signaling in lung tissue remodeling associated with IPF and IPAH.
Analyzed the expression and histological distribution of FGF ligands (FGF7, FGF10) and their receptors (FGFR1, FGFR2) in human lung tissue from IPF and IPAH patients compared with healthy donor controls.
Assessed ligand and receptor expression levels across zones of active parenchymal remodeling in IPF and correlated expression profiles with hemodynamic severity in IPAH.
FGF7, FGF10, and FGFR2 were significantly upregulated in IPF and IPAH lungs compared to donor lungs, localizing to remodeled parenchyma and vasculature, while FGFR1 expression showed no significant change.
Expression levels of FGF7, FGF10, and FGFR2 were reduced in areas of active IPF remodeling and were inversely correlated with IPAH severity, pointing to a protective repair response rather than a pathological driver.

Cite This Study

Agha et al. (2018) studied this question.

synapsesocial.com/papers/6a70ae01e5469ee92be16224 https://doi.org/10.1152/ajplung.00140.2018

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Implication

Translational study demonstrates protective FGF7, FGF10, and FGFR2 upregulation in IPF and IPAH lungs, suggesting broad kinase inhibitors may hinder natural pulmonary repair mechanisms.

Is the fibroblast growth factor signaling pathway a victim of receptor tyrosine kinase inhibition in pulmonary parenchymal and vascular remodeling?

Discussion

Member takes

Implication

Key Points

Cite This Study

Is the fibroblast growth factor signaling pathway a victim of receptor tyrosine kinase inhibition in pulmonary parenchymal and vascular remodeling?

Discussion

Member takes

Implication

Key Points

Cite This Study

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