Serum C₃ and C₄ complement components were estimated in patients with Crohn’s disease and ulcerative colitis. In Crohn’s disease, serum C₄ concentrations were significantly higher than those of controls. In ulcerative colitis, significantly higher concentrations of C₃ and C₄ were associated with severe or extensive disease, and C₄ concentrations may remain high, years after total colectomy.
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Ward et al. (2009) studied this question.
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