Why the study?
Does RAAS inhibition improve endothelial dysfunction in type 2 diabetic models by reducing AT1R-dependent oxidative stress?
Population
db/db mice and renal arteries from diabetic patients (fasting plasma glucose level ≥7.0 mmol/l)
Comparison
Daily oral administration of valsartan or… vs Untreated db/db mice and untreated diabetic…
Design
Preclinical
Follow-up
6 weeks
Authors
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Supports RAAS inhibition for endothelial dysfunction in diabetic models; leaves open translation to human type 2 diabetes.
Does RAAS inhibition improve endothelial dysfunction in type 2 diabetic models by reducing AT1R-dependent oxidative stress?
This study demonstrates that AT1R-dependent oxidative stress mediates endothelial dysfunction in type 2 diabetes, which can be reversed by RAAS inhibition.
Wong et al. (2010) studied this question.
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