June 20, 2006Hypertension
Angiotensin Receptor Blocker Added to Previous Antihypertensive Agents on Arteries of Diabetic Hypertensive Patients
Why the study?
Does the addition of valsartan compared to atenolol improve resistance artery remodeling in hypertensive type 2 diabetic patients on previous antihypertensive therapy?
Population
28 hypertensive type 2 diabetic patients treated with oral hypoglycemic and antihypertensive agents
Comparison
Valsartan added to previous antihypertensive… vs Atenolol added to previous antihypertensive…
Design
RCT, randomly assigned, double-blind
Follow-up
1 year
Authors
Discussion
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Implication
Valsartan addition improves resistance artery remodeling versus atenolol in hypertensive T2D; extends evidence of ARB-specific microvascular benefits in RCT.
Structured PICO
Does the addition of valsartan compared to atenolol improve resistance artery remodeling in hypertensive type 2 diabetic patients on previous antihypertensive therapy?
P
Population
28 hypertensive type 2 diabetic patients treated with oral hypoglycemic and antihypertensive agents (including ACEIs and/or CCBs, but not receiving ARBs or BBs)
I
Intervention
Valsartan (80 to 160 mg daily) added to previous antihypertensive therapy for 1 year
C
Comparator
Atenolol (50 to 100 mg daily) added to previous antihypertensive therapy for 1 year
O
Outcome
Remodeling of resistance arteries (media:lumen ratio) from gluteal subcutaneous tissues assessed on a pressurized myograph after 1 yearsurrogate
The addition of valsartan, but not atenolol, to standard antihypertensive therapy improves resistance artery remodeling in hypertensive patients with type 2 diabetes.
Cite This Study
Savoia et al. (2006) studied this question.