Why the study?
Does losartan improve conduit vessel endothelial function in subjects with Type II diabetes?
Population
12 subjects with Type II diabetes
Comparison
Losartan 50 mg daily for 4 weeks vs Placebo (crossover design)
Design
RCT, randomized crossover protocol, double-blind
Follow-up
4 weeks
Authors
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Losartan improves endothelial function in type 2 diabetes; supports its role as an ACE inhibitor alternative and extends prior observations.
Does losartan improve conduit vessel endothelial function in subjects with Type II diabetes?
Losartan 50 mg daily improves NO-mediated dilation in conduit vessels of subjects with Type II diabetes, offering an alternative to ACE inhibitors for maintaining endothelial function.
Cheetham et al. (2000) studied this question.
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