Why the study?
Does losartan improve endothelial function of epicardial coronary arteries in patients with essential hypertension?
Population
30 patients with mild to moderate essential hypertension and 30 matched healthy subjects (n=60)
Comparison
Losartan administration for 12 weeks vs Pre-treatment baseline and matched healthy…
Design
Cohort
Follow-up
12 weeks
Authors
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Losartan was associated with improved coronary endothelial function in hypertension; hypothesis-generating and requires randomized confirmation before practice change.
Does losartan improve endothelial function of epicardial coronary arteries in patients with essential hypertension?
Losartan improves coronary endothelial function in patients with mild to moderate essential hypertension, independent of its blood pressure-lowering effect.
Deng et al. (2002) studied this question.
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