March 1, 2002EndocrinologyOpen Access

Distribution, Neuronal Colocalization, and 17β-E2 Modulation of Small Conductance Calcium-Activated K+ Channel (SK3) mRNA in the Guinea Pig Brain

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Population

Female guinea pig brain models

Design

Preclinical

Authors

MBMartha A. BoschOregon Health & Science University MKMartin J. KellyThe Alfred Hospital OROline K. RønnekleivOregon National Primate Research Center

Discussion

Member takes

Implication

Hypothesis-generating for SK3 in estrogen feedback; leaves open human relevance and requires prospective validation.

Structured PICO

Population

Female guinea pig brain models

Intervention

17beta-E2 treatment

Outcome

SK3 mRNA expression levels and distributionsurrogate

Estrogen increases the mRNA expression of SK3 channels, suggesting a mechanism for regulating hypothalamic neuronal excitability during negative feedback.

Cite This Study

Bosch et al. (2002) studied this question.

synapsesocial.com/papers/6a70b07078a11c550e0aaa42 https://doi.org/10.1210/endo.143.3.8708

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Distribution, Neuronal Colocalization, and 17β-E2 Modulation of Small Conductance Calcium-Activated K+ Channel (SK3) mRNA in the Guinea Pig Brain

Discussion

Member takes

Implication

Structured PICO

Cite This Study

Distribution, Neuronal Colocalization, and 17β-E2 Modulation of Small Conductance Calcium-Activated K+ Channel (SK3) mRNA in the Guinea Pig Brain

Discussion

Member takes

Implication

Structured PICO

Cite This Study

Also Consider

Also Consider