June 1, 2002Obesity Research
Obesity Increases the Risk of Spontaneous Abortion during Infertility Treatment
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Discussion
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Implication
Retrospective study reveals elevated spontaneous abortion risk in overweight and obese women undergoing infertility treatment, highlighting weight management as an actionable target.
Key Points
- To assess the relationship between maternal body mass index and the incidence of spontaneous abortion among patients conceiving through infertility treatment.
- Retrospective analysis of pregnancies (n = 2349) achieved following infertility treatment at a tertiary medical center between 1987 and 1999, including one pregnancy per subject.
- Participants were stratified by body mass index: underweight (<18.5 kg/m²), normal (18.5–24.9 kg/m²), overweight (25–29.9 kg/m²), obese (30–34.9 kg/m²), and very obese (≥35 kg/m²).
- Multivariable logistic regression was performed to evaluate spontaneous abortion risk across BMI groups after adjusting for independent risk factors.
- The overall incidence of spontaneous abortion across the cohort was 20% (476 of 2349).
- Underweight women experienced a spontaneous abortion risk similar to the normal BMI reference group, whereas risk increased progressively among overweight (p < 0.05), obese (p < 0.01), and very obese groups (p < 0.001).
Cite This Study
Wang et al. (2002) studied this question.