Why the study?
Nonclinical evaluations of delayed repolarization minimally influence clinical QTc prolongation assessment strategies, and the value of nonclinical ICH S7B double-negative findings remains underappreciated.
Design
Review
Authors
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May support integrated nonclinical-clinical QTc risk models; leaves open whether they can streamline or replace ICH S7B/E14 assays.
Key points are not available for this paper at this time.
Vargas et al. (2020) studied this question.
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