Key result
Redeploying developmental factors augments endogenous cardiomyocyte turnover to promote cardiac regeneration.
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Heart failure is a major source of morbidity and mortality. Replacing lost myocardium with new tissue is a major goal of regenerative medicine. Unlike adult mammals, zebrafish and neonatal mice are capable of heart regeneration following cardiac injury. In both contexts, the regenerative program echoes molecular and cellular events that occur during cardiac development and morphogenesis, notably muscle creation through division of cardiomyocytes. Based on studies over the past decade, it is now accepted that the adult mammalian heart undergoes a low grade of cardiomyocyte turnover. Recent data suggest that this cardiomyocyte turnover can be augmented in the adult mammalian heart by redeployment of developmental factors. These findings and others suggest that stimulating endogenous regenerative responses can emerge as a therapeutic strategy for human cardiovascular disease.
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Karra et al. (2017) conducted a review in Heart failure and cardiovascular disease. Redeployment of developmental factors / stimulating endogenous regenerative responses was evaluated on Cardiomyocyte turnover and therapeutic cardiac regeneration. Redeployment of developmental factors can augment endogenous cardiomyocyte turnover in adult mammalian hearts as a potential therapeutic strategy for cardiovascular disease.
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