Why the study?
Does sar1-leu8-angiotensin II reverse the effects of captopril on renal function and blood pressure in Inactin-anaesthetized rats?
Does sar1-leu8-angiotensin II reverse the effects of captopril on renal function and blood pressure in Inactin-anaesthetized rats?
Sar1-leu8-angiotensin II exhibits partial agonist activity in the kidney while acting as an antagonist in the systemic circulation, suggesting distinct angiotensin receptor subtypes.
No immediate clinical implications from this rat model; leaves open distinct renal versus systemic angiotensin receptor subtypes.
In Inactin-anaesthetized rats inhibition of angiotensin converting enzyme by captopril resulted in a small decrease in mean arterial blood pressure accompanied by increases in the rates of glomerular filtration, water and electrolyte excretion. Infusion (100 pmol/min) of sar1-leu8-angiotensin II (sar1-leu8-AII) during continuing converting enzyme blockade reversed these changes in renal function but had no effect on arterial blood pressure. The data indicate that sar1-leu8-AII has partial agonist activity in the kidney although it acts as an antagonist of AII in the systemic circulation. This supports the proposal that angiotensin receptors within the kidney differ from those in the peripheral circulation.
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Harris et al. (1986) studied this question.
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