Powerful Chiral Phase‐Transfer Catalysts for the Asymmetric Synthesis of α‐Alkyl‐ and α,α‐Dialkyl‐α‐amino Acids

The catalytic performance of the chiral phase-transfer catalyst 1 (0.1–0.01 mol %) in the asymmetric alkylation of protected glycine and alanine derivatives exceeds that of existing catalysts. The reaction is used in the enantioselective synthesis of structurally diverse natural and non-natural α-alkyl and α,α-dialkyl-α-amino acids.