September 28, 2007Arthritis Care & ResearchOpen Access

International consensus on a proposed score system for muscle biopsy evaluation in patients with juvenile dermatomyositis: A tool for potential use in clinical trials

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Population

33 muscle biopsy samples obtained from children diagnosed with juvenile dermatomyositis (DM)

Design

Other

Authors

LWLucy R. WedderburnUniversity of London HVHemlata VarsaniVersus Arthritis CLCharles K.-C. LiRoyal Surrey County Hospital

Discussion

Member takes

Implication

Supports standardized JDM biopsy assessment among experts; prospective validation needed before clinical adoption.

Structured PICO

Population

33 muscle biopsy samples obtained from children diagnosed with juvenile dermatomyositis (DM)

Intervention

Proposed scoring system for muscle biopsy evaluation based on 4 domains (inflammatory, vascular, muscle fiber, and connective tissue) and a global abnormality measure (VAS 0-10)

Outcome

Reliability (intraclass correlation coefficient) and scorer agreement (alpha) of the scoring tool

A provisional scoring system for evaluating muscle biopsy abnormalities in juvenile dermatomyositis demonstrated high reliability and agreement among experts.

Cite This Study

Wedderburn et al. (2007) studied this question.

synapsesocial.com/papers/6a70b219e5469ee92be164c6 https://doi.org/10.1002/art.23012

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International consensus on a proposed score system for muscle biopsy evaluation in patients with juvenile dermatomyositis: A tool for potential use in clinical trials

Discussion

Member takes

Implication

Structured PICO

Cite This Study

International consensus on a proposed score system for muscle biopsy evaluation in patients with juvenile dermatomyositis: A tool for potential use in clinical trials

Discussion

Member takes

Implication

Structured PICO

Cite This Study

Also Consider

Also Consider