Why the study?
Does experimental sepsis downregulate Angiotensin II type 1 receptors and attenuate blood pressure response to Angiotensin II in rats?
Population
Rats with experimental Gram-negative and Gram-positive sepsis, and in vitro rat renal mesangial cells
Comparison
Experimental sepsis and exposure to NO and… vs Normal rats and control cells
Design
Preclinical
Authors
Loading...
May underlie vasopressor hyporesponsiveness in sepsis; hypothesis-generating for AT1-targeted therapies in human septic shock.
Does experimental sepsis downregulate Angiotensin II type 1 receptors and attenuate blood pressure response to Angiotensin II in rats?
Sepsis-induced downregulation of Angiotensin II type 1 receptors, mediated by NO and cytokines, explains the attenuated cardiovascular responsiveness and contributes to the pathophysiology of septic shock.
Bucher et al. (2001) studied this question.
Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context: