What question did this study set out to answer?

Determine the molecular receptor mediating virulence activation and cross-group inhibition in Staphylococcus aureus to guide the rational design of a broad-spectrum virulence inhibitor.

November 21, 2000Proceedings of the National Academy of SciencesOpen Access

Rational design of a global inhibitor of the virulence response in Staphylococcus aureus , based in part on localization of the site of inhibition to the receptor-histidine kinase, AgrC

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Authors

GLGholson J. LyonThe Graduate Center, CUNY PMPatricia MayvilleRutgers, The State University of New Jersey TMTom W. MuirPrinceton University

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Implication

Experimental study reveals that AgrC mediates both activation and inhibition across Staphylococcus aureus groups, suggesting a path for broad-spectrum anti-virulence peptides.

Key Points

Determine the molecular receptor mediating virulence activation and cross-group inhibition in Staphylococcus aureus to guide the rational design of a broad-spectrum virulence inhibitor.
Exchanged the AgrC receptor-histidine kinase between Staphylococcus aureus strains belonging to different agr specificity groups.
Synthesized and evaluated a truncated derivative of a native thiolactone autoinducing peptide to test for broad-spectrum virulence inhibition.
AgrC receptor-switching experiments demonstrated that both intragroup activation and intergroup cross-inhibition of virulence are governed directly by the group-specific AgrC kinase.
A truncated version of a natural thiolactone peptide acted as a global inhibitor, successfully blocking agr-driven virulence signaling across multiple S. aureus specificity groups.

Cite This Study

Lyon et al. (2000) studied this question.

synapsesocial.com/papers/6a70b28726a7f98052dd2b89 https://doi.org/10.1073/pnas.97.24.13330

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Implication

Experimental study reveals that AgrC mediates both activation and inhibition across Staphylococcus aureus groups, suggesting a path for broad-spectrum anti-virulence peptides.

Rational design of a global inhibitor of the virulence response in Staphylococcus aureus , based in part on localization of the site of inhibition to the receptor-histidine kinase, AgrC

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Implication

Key Points

Cite This Study

Rational design of a global inhibitor of the virulence response in Staphylococcus aureus , based in part on localization of the site of inhibition to the receptor-histidine kinase, AgrC

Discussion

Member takes

Implication

Key Points

Cite This Study

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