Why the study?
Does adjusted-dose warfarin reduce ischemic stroke compared to antiplatelet therapy in patients with systolic heart failure and sinus rhythm?
Does adjusted-dose warfarin reduce ischemic stroke compared to antiplatelet therapy in patients with systolic heart failure and sinus rhythm?
In patients with systolic heart failure and sinus rhythm, warfarin reduces ischemic stroke but increases major hemorrhage compared to antiplatelet therapy, with no significant effect on mortality or heart failure hospitalization.
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Reduces ischemic stroke at the cost of major hemorrhage in systolic HF with sinus rhythm; confirms no mortality or HF hospitalization benefit.
Liew et al. (2013) studied this question.
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