Why the study?
Human sinoatrial node cell data recently became available, leading to a published human SAN cell model and CellML version that required reproduction of its main results.
The Fabbri et al. 2017 mathematical model of the human sinus node action potential can be successfully reproduced using open-source CellML and Python tools.
Human SAN models enable species-specific simulations; leaves open clinical translation pending validation.
The sinoatrial node (SAN) is the natural pacemaker of the mammalian heart. It has been the the subject of several mathematical studies, aimed at reproducing its electrical response under normal sinus rhythms, as well as under various conditions. Such studies were traditionally done using data from rabbit SAN cells. More recently, human SAN cell data have become available, resulting in the publication of a human SAN cell model (Fabbri et al., 2017), along with its CellML version. Here, we used the CellML file provided by the model authors, together with some SED-ML files and Python scripts that we created to reproduce the main results of the aforementioned modeling study.
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Afshar et al. (2021) studied this question.
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