Why the study?
A human sinoatrial node cell model was recently published, and this study aimed to reproduce its main results using its CellML version.
The human sinus node action potential model by Fabbri et al. (2017) is successfully reproducible using open-source CellML and Python implementations.
Human SAN models extend rabbit-based simulations; leaves open validation before informing sinus node therapies.
The sinoatrial node (SAN) is the natural pacemaker of the mammalian heart. It has been the subject of several mathematical studies, aimed at reproducing its electrical response under normal sinus rhythms, as well as under various conditions. Such studies were traditionally done using data from rabbit SAN cells. More recently, human SAN cell data have become available, resulting in the publication of a human SAN cell model (Fabbri et al., 2017), along with its CellML version. Here, we used the CellML file provided by the model authors, together with some SED-ML files and Python scripts that we created to reproduce the main results of the aforementioned modeling study. EDITOR'S NOTE (v2): this article and its OMEX archive are republished with technical changes made to the corresponding Python scripts to remove a run-time error message displayed when executing each simulation.
No takes yet. Share an insight, caveat, or question.
Afshar et al. (2021) studied this question.
Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context: