Why the study?
Can action potential simulations based on early ion channel screens predict human Thorough QT study results?
Can action potential simulations based on early ion channel screens predict human Thorough QT study results?
Action potential simulations using early in vitro ion channel screening data can predict clinical QT prolongation with high specificity, offering a potential tool for early cardiac safety assessment in drug development.
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May inform early cardiac safety screening in drug development; leaves open reliable prediction of human QT effects.
Mirams et al. (2014) studied this question.
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