Why the study?
The endocrine and cardiology interface is clinically important, but classical endocrine diseases presenting with MINOCA are often overlooked.
Highlights that classical endocrine diseases can present with MINOCA, suggesting that patients without traditional risk factors should undergo hormonal workup.
Endocrine etiologies may underlie select MINOCA cases; hypothesis-generating and requires validation in larger cohorts.
The endocrine and cardiology interface is particularly interesting and important. This is a case series of 3 endocrine diseases presenting with acute myocardial infarction without obstructive coronary arterial diseases (MINOCA). The diagnosis was Cushing's disease due to pituitary microadenoma, adrenal pheochromocytoma, and primary hyperaldosteronism due to unilateral adrenal hyperplasia. All patients were managed conservatively and improved considerably following the management of underlying endocrine and cardiovascular diseases. A spectrum of classical endocrine diseases can present with MINOCA, and the underlying diagnosis is often overlooked. Patients without traditional risk factors for MINOCA should undergo hormonal workup to reveal the underlying diagnosis.
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Roy et al. (2025) studied this question.
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