Structural and thermodynamic consequences of burying a charged residue within the hydrophobic core of T4 lysozyme

Also Consider

Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context:

1. 1Second-site revertants of an inactive T4 lysozyme mutant restore activity by restructuring the active site cleft1991 · 103 citations
2. 2Genetic and structural analysis of the protein stability problem1987 · 227 citations
3. 3pH-Induced denaturation of proteins: a single salt bridge contributes 3-5 kcal/mol to the free energy of folding of T4 lysozyme1990 · 523 citations
4. 4Purification of Bacteriophage T4 Lysozyme1968 · 225 citations
5. 5Contributions of engineered surface salt bridges to the stability of T4 lysozyme determined by directed mutagenesis1991 · 240 citations