A New Role for the Muscle Repair Protein Dysferlin in Endothelial Cell Adhesion and Angiogenesis

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Structured PICO

Population

Cultured endothelial cells, intact and diseased blood vessels of rodent and human origin, and dysferlin-null mice

Intervention

Loss of dysferlin (via gene silencing or knockout) and adenovirus-mediated gene transfer of PECAM-1

Comparator

Control mice and control endothelial cells

Outcome

Endothelial cell adhesion, growth arrest, and angiogenic responsesurrogate

Dysferlin plays a novel role in regulating endothelial cell adhesion and angiogenesis by preventing the proteasomal degradation of PECAM-1.

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Dysferlin may regulate endothelial angiogenesis in mice; leaves open its therapeutic relevance in human vascular disease.

Sharma et al. (2010) studied this question.

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