Studies with methionine-vitamin Blz auxotrophs of Escherichia coli have established that the terminal step in methionine formation involves the transfer of the methyl group from Aremethyltetrahydrofolic acid to homocysteine (Reaction 1) (1, 2).Methylfolate-Hc S-adenosylmethionine (11 + homocysteine Bn-protem .I reducing system ) methionine S-Adenosylmethionine (3, 4), a cobamide protein (5-7), and a reducing system (8, 9) are required for the methyl transfer.
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Weissbach et al. (1964) studied this question.