Why the study?
Does furosemide compared with hydrochlorothiazide improve blood pressure reduction in hypertensive patients?
Does furosemide compared with hydrochlorothiazide improve blood pressure reduction in hypertensive patients?
Hydrochlorothiazide provides greater systolic blood pressure reduction than furosemide in hypertensive patients, likely due to its longer duration of action.
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Hydrochlorothiazide may be preferred over furosemide for systolic BP reduction; reinforces thiazide priority in hypertension guidelines.
In a double-blind crossover study, the effectiveness of furosemide, 40 mg twice daily, was compared with hydrochlorothiazide, 50 mg twice daily, in hypertensive patients. Both hydrochlorothiazide and furosemide significantly reduced blood pressure (BP) during three months of therapy. However, the fall in BP was consistently greater with hydrochlorothiazide than with furosemide, although the difference was significant only with respect to systolic BP. The somewhat greater antihypertensive effectiveness of hydrochlorothiazide may be related to its longer action permitting a more continuous diuretic effect and, hence, maintenance of reduced extracellular fluid volume throughout the 24-hour period. (JAMA240:1863-1866, 1978)
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M A Araoye (1978) studied this question.
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