Why the study?
Does caloric restriction reduce mortality and improve cardiac and mitochondrial function in senescent rats?
Population
Young and senescent rats, as well as H9C2 cardiomyoblasts and adult rat ventricular cardiomyocytes for in…
Comparison
Long-term caloric restriction (-40% for 6 months) vs Age-matched rats on a control diet
Design
Preclinical
Follow-up
6 months
Authors
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Hypothesis-generating in senescent rats; leaves open translation to human cardiac aging.
Does caloric restriction reduce mortality and improve cardiac and mitochondrial function in senescent rats?
Caloric restriction provides cardioprotection in senescent myocardium by correcting mitochondrial dysfunction and apoptotic activation, effects that appear to be mediated by circulating factors.
Niemann et al. (2010) studied this question.
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