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March 28, 2021NutrientsOpen Access

Effect of Training-Detraining Phases of Multicomponent Exercises and BCAA Supplementation on Inflammatory Markers and Albumin Levels in Frail Older Persons

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Authors

ACAdriana Caldo‐SilvaUniversity of CoimbraGFGuilherme Eustáquio FurtadoPolytechnic Institute of CoimbraMCMatheus Uba ChupelUniversity of Coimbra

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Implication

Controlled trial shows reduced inflammation and improved albumin with exercise and amino acids in frail older adults, suggesting better physical function and independence.

Key Points

  • Investigate the impact of a 40-week multifactorial intervention combining multicomponent exercise and branched-chain amino acid supplementation on inflammatory markers, albumin levels, and physical function in frail older care home residents.
  • Prospective, naturalistic, controlled clinical trial conducted with 35 frail older adults (≥75 years) assigned to four arms: ME + BCAAs (n=8), ME (n=7), BCAAs (n=7), and control (n=13).
  • Followed a 40-week intervention-washout-intervention schedule featuring 16 weeks of intervention, an 8-week washout period, and a subsequent 16 weeks of intervention.
  • Assessed lower limb muscle strength, cognitive profile, physical frailty, plasma albumin, IL-10, TNF-α, TNF-α/IL-10 ratio, and myeloperoxidase activity at four time points.
  • Multicomponent exercise paired with branched-chain amino acids produced improvements in cognitive profile and muscle strength-related albumin levels.
  • Plasma concentrations of the pro-inflammatory cytokine TNF-α decreased specifically in the combined multicomponent exercise and branched-chain amino acid group.
  • No significant changes over time were detected in the TNF-α/IL-10 ratio or myeloperoxidase activity across the intervention groups.

Cite This Study

Caldo‐Silva et al. (2021) studied this question.

synapsesocial.com/papers/6a70b96575498292b70a2ef6https://doi.org/10.3390/nu13041106
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