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July 1, 1989The Anatomical Record

Three‐dimensional reconstruction of the myofiber pattern in the fetal and neonatal mouse heart

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Population

Fetal and neonatal mouse heart (ventricles)

Design

Preclinical

Authors

MMMiriam McLeanUniversity of WashingtonMRM. Alison RossUniversity of WashingtonJPJohn ProtheroUniversity of Washington

Discussion

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Implication

Animal data on myocardial patterning should not alter practice; leaves open translation to human fetal cardiology.

Structured PICO

P
Population
Fetal and neonatal mouse heart (ventricles)
I
Intervention
Three-dimensional reconstruction from serial sections and interactive computer graphics
O
Outcome
Morphogenesis of the cardiac myofiber pattern

The study demonstrates that the global myofiber pattern in the fetal and neonatal mouse heart is complex, particularly in and adjacent to the interventricular septum, and develops rapidly after 12 days postconception.

Cite This Study

McLean et al. (1989) studied this question.

synapsesocial.com/papers/6a70b96a2163a0a01bc4ef08https://doi.org/10.1002/ar.1092240308
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Also Consider

Synapse has enriched 4 closely related papers on similar clinical questions. Consider them for comparative context:

  1. 1An engineering analysis of myocardial fiber orientation in pig's left ventricle in systole1966 · 184 citations
  2. 2Relationship between myocardial fiber direction and segment shortening in the midwall of the canine left ventricle.1985 · 96 citations
  3. 3Fiber Orientation in the Canine Left Ventricle during Diastole and Systole1969 · 1,464 citations
  4. 4Fiber orientation in hypertrophied canine left ventricle1979 · 38 citations