Key result
Loss of ancestral cold stress and sleep-calorie interactions may drive modern cardiometabolic disease.
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Cronise et al. (2014) conducted a review in Obesity and cardiometabolic disease. Calorie scarcity, mild cold stress, and sleep vs. Excessive caloric consumption was evaluated on Prevalence of nutritionally related diseases (obesity and cardiometabolic disease). Interactions among calorie scarcity, mild cold stress, and sleep are proposed to explain the rising prevalence of obesity and cardiometabolic disease in the era of caloric excess.
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