Exercise-induced ischemia: the influence of altered relaxation on early diastolic pressures.
Why the study?
How does exercise-induced ischemia alter left ventricular pressure decay and early diastolic pressures compared to normal responses or prior infarction without ischemia?
Population
24 patients comprising three groups: ischemia group with coronary artery disease and exercise-induced…
Comparison
Exercise vs Rest and comparison between ischemia, control…
Design
Cohort
Authors
Discussion
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Member takes
Implication
May underlie exertional symptoms in ischemia; extends LV relaxation observations to exercise and leaves open clinical translation.
Structured PICO
How does exercise-induced ischemia alter left ventricular pressure decay and early diastolic pressures compared to normal responses or prior infarction without ischemia?
P
Population
24 patients comprising three groups: ischemia group (n=15) with coronary artery disease and exercise-induced regional wall motion abnormalities documented by biplane LV cineangiography; control group (n=4) with normal exercise response; scar group (n=5) with prior infarction, akinetic scars and no ischemia with exercise.
I
Intervention
Exercise
C
Comparator
Rest (baseline) and comparison between ischemia, control, and scar groups
O
Outcome
Left ventricular pressure (LVP) decay and early diastolic pressures (including minimal LV diastolic pressure, time constant of LVP decay, and extrapolated baseline pressure)surrogate
Exercise-induced ischemia causes severe elevation of early diastolic pressures due to both delayed left ventricular relaxation and an upward shift in baseline pressure.
Cite This Study
Carroll et al. (1983) studied this question.