Why the study?
What are the mechanical determinants of the time course of left ventricular pressure decline during isovolumic relaxation in the intact heart?
What are the mechanical determinants of the time course of left ventricular pressure decline during isovolumic relaxation in the intact heart?
Left ventricular relaxation is dependent on systolic pressure, but other factors such as baroreceptor reflex activity may superimpose on this load-dependency in the intact heart.
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Site-specific aortic constriction differentially modulates LV relaxation beyond systolic pressure alone; extends animal models but leaves open human translation.
Gaasch et al. (1980) studied this question.
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