Why the study?
Does the change in loading sequence affect LV regional wall motion and LV relaxation in intact dogs?
Population
7 anesthetized dogs
Comparison
Early and late systolic loading produced by… vs Comparison between mild and moderate…
Design
Preclinical
Authors
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Regional nonuniformity may mediate afterload effects on LV relaxation in dogs; leaves open human relevance.
Does the change in loading sequence affect LV regional wall motion and LV relaxation in intact dogs?
Left ventricular regional nonuniformity between basal and apical regions appears to be involved in the complex mechanism of afterload-dependent relaxation.
Yano et al. (1994) studied this question.
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