Population
10 canine isolated heart-lung preparations
Comparison
Load step of 15 mmHg imposed at specific… vs The beat preceding the load intervention
Design
Preclinical
Authors
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Timing-dependent systolic load effects on relaxation in canines; leaves open relevance to human diastolic function.
In a canine model, the timing of systolic loading is a critical determinant of ventricular relaxation, with early loading prolonging and late loading abbreviating the relaxation time constant.
Zatko et al. (1987) studied this question.
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