Why the study?
Does loading sequence determine afterload-dependent relaxation in intact canine hearts?
Population
9 anesthetized open-chest dogs under pharmacological blockade of autonomic nerve activity
Comparison
Afterload change imposed by clamping the… vs Contractions with the peak LV pressure in early…
Design
Preclinical
Authors
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Altered loading sequence may slow LV relaxation in intact canine hearts; leaves open translation to human diastolic function.
Does loading sequence determine afterload-dependent relaxation in intact canine hearts?
This study demonstrates that afterload-dependent slowed relaxation in intact hearts is driven by the altered loading sequence rather than an increased total load.
Hori et al. (1985) studied this question.
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