Why the study?
Does loading sequence determine afterload-dependent relaxation in intact canine hearts?
Does loading sequence determine afterload-dependent relaxation in intact canine hearts?
This study demonstrates that afterload-dependent slowed relaxation in intact hearts is driven by the altered loading sequence rather than an increased total load.
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Altered loading sequence may slow LV relaxation in intact canine hearts; leaves open translation to human diastolic function.
Hori et al. (1985) studied this question.
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