Why the study?
Does an increase in afterload augment ventricular relaxation rate in isolated perfused canine hearts?
Population
Isolated perfused canine hearts
Comparison
Volume loading evaluated using an exponential… vs Semilogarithmic method assuming P chi = 0
Design
Preclinical
Authors
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Challenges load-insensitivity assumptions in canine models; leaves open translation to human ventricular physiology.
Does an increase in afterload augment ventricular relaxation rate in isolated perfused canine hearts?
In isolated canine hearts, increasing afterload augments the ventricular relaxation rate when evaluated using an exponential method with a variable asymptote LV pressure, challenging previous assumptions of load-insensitivity.
Hori et al. (1985) studied this question.
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