Why the study?
Does reoxygenation after acute hypoxia prolong left ventricular relaxation and increase diastolic stiffness in intact dog hearts?
Population
22 anesthetized dogs subjected to 15 minutes of hypoxia (PaO2 = 21 +/- 2 mm Hg)
Comparison
Reoxygenation vs Control levels (baseline prior to reoxygenation)
Design
Preclinical
Follow-up
5 minutes of reoxygenation
Authors
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Reoxygenation may impair diastolic filling when diastole is short; leaves open relevance to human reperfusion injury.
Does reoxygenation after acute hypoxia prolong left ventricular relaxation and increase diastolic stiffness in intact dog hearts?
Rapid correction of acute hypoxia in the intact dog heart results in prolonged LV relaxation, which can increase LV end-diastolic stiffness when diastole is sufficiently short.
Blaustein et al. (1981) studied this question.
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