Pentoxifylline in Ischemic, Hypertensive and Idiopathic-Dilated Cardiomyopathy: Effects on Left-Ventricular Function, Inflammatory Cytokines and Symptoms

47 patients with compensated congestive heart failure (CHF) and LVEF ≤40% (31.9% ischemic, 21.3% hypertensive, 10.6% ischemic and hypertensive, 36.2% idiopathic-dilated cardiomyopathy), on standard treatment (angiotensin-converting enzyme inhibitors, diuretics, and beta-blockers) for at least 3 months.

Pentoxifylline 600 mg BID for 6 months

Placebo for 6 months

Left-ventricular ejection fraction (LVEF) assessed by contrast 2D echocardiography at 6 monthssurrogate