Fetuin-A (α2-Heremans Schmid glycoprotein) is a circulating glycoprotein that can inhibit insulin receptor autophosphorylation and subsequent downstream signaling in vitro (1, 2). Recently, it has been reported (3) that fetuin-A–deficient mice demonstrate enhanced insulin sensitivity. These data indicate that fetuin-A might be a negative regulator of insulin signaling. However, the physiological significance of fetuin-A in insulin resistance in humans remains unclear. To address this, we investigated the relationship of serum fetuin-A levels and insulin resistance in nondiabetic ( n = 160) and type 2 diabetic ( n = 161) subjects. Serum fetuin-A was measured by an enzyme-linked immunosorbent assay kit (BioVender Laboratory Medicine, …
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Mori et al. (2006) studied this question.
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