What question did this study set out to answer?

To evaluate the use of nucleic acid aptamers as targeted delivery vehicles for the tumor suppressor microRNA let-7g in Axl-expressing cancers.

January 20, 2014Molecular TherapyOpen Access

Multifunctional Aptamer-miRNA Conjugates for Targeted Cancer Therapy

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To evaluate the use of nucleic acid aptamers as targeted delivery vehicles for the tumor suppressor microRNA let-7g in Axl-expressing cancers.
Generated multifunctional conjugates linking the let-7g microRNA to GL21.T, an aptamer targeting the oncogenic receptor tyrosine kinase Axl.
Assessed targeted cellular uptake, processing by the RNA interference machinery, let-7g target gene knockdown in vitro, and tumor progression in a lung adenocarcinoma mouse xenograft model.
The GL21.T–let-7g conjugate demonstrated selective internalization into Axl-expressing target cells, successful processing by the intracellular RNA interference pathway, and effective silencing of let-7g target genes.
Treatment with the multifunctional aptamer-miRNA conjugate inhibited tumor growth in an in vivo lung adenocarcinoma xenograft model.

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Implication

Preclinical study demonstrates reduced tumor growth in lung adenocarcinoma xenografts, highlighting aptamer-guided microRNA delivery as an effective anticancer strategy.

Cite This Study

Esposito et al. (2014) studied this question.

synapsesocial.com/papers/6a70bde478a11c550e0ab9be https://doi.org/10.1038/mt.2014.5

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Implication

Preclinical study demonstrates reduced tumor growth in lung adenocarcinoma xenografts, highlighting aptamer-guided microRNA delivery as an effective anticancer strategy.

Multifunctional Aptamer-miRNA Conjugates for Targeted Cancer Therapy

Key Points

Discussion

Implication

Cite This Study

Multifunctional Aptamer-miRNA Conjugates for Targeted Cancer Therapy

Key Points

Discussion

Implication

Cite This Study

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