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January 1, 2010Journal of Atherosclerosis and ThrombosisOpen Access

Changes in Cardio-Ankle Vascular Index in Smoking Cessation

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Why the study?

Does smoking cessation improve arterial stiffness as measured by the cardio-ankle vascular index (CAVI) in smokers?

Population

102 subjects. Smokers: 77 men, mean age 64±10 years. Non-smokers: 18 men, mean age 61±7 years. Exclusions…

Comparison

Smoking cessation vs Non-smokers and baseline pre-cessation values

Design

Cohort

Follow-up

3 months

Authors

HNHirofumi NoikeToho UniversityKNK NakamuraGunma Prefectural Cardiovascular CenterYSYuukou SugiyamaThe University of Tokyo

Discussion

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Implication

Complete cessation may improve arterial stiffness; leaves open whether CAVI changes predict outcomes in prospective trials.

Structured PICO

Does smoking cessation improve arterial stiffness as measured by the cardio-ankle vascular index (CAVI) in smokers?

P
Population
102 subjects (82 smokers, 20 non-smokers). Smokers: 77 men, mean age 64±10 years. Non-smokers: 18 men, mean age 61±7 years. Exclusions: ankle/brachial blood pressure ratio ≤0.9, arrhythmia, recent medication changes, untreated angina pectoris, acute myocardial infarction, valvular disease, renal failure, heart failure (ejection fraction <50%) and age over 80 years.
I
Intervention
Smoking cessation (classified as 'success' for complete abstinence, 'partial success' for reduced cigarette consumption, and 'failure' for unchanged or increased consumption)
C
Comparator
Non-smokers (n=20) and baseline pre-cessation values
O
Outcome
Change in cardio-ankle vascular index (CAVI) and CAVI severity levels at 3 monthssurrogate

Complete smoking cessation significantly improves arterial stiffness as measured by the cardio-ankle vascular index (CAVI) within 3 months, whereas reducing cigarette consumption has little effect.

Limitations

  • Very few subjects in this study, excluding failed smoking cessation
  • Data on smoking characteristics were collected via self-report and lacked objectivity
  • Mechanisms must be elucidated via a multi-angled approach

Cite This Study

Noike et al. (2010) studied this question.

synapsesocial.com/papers/6a70be5626a7f98052dd3481https://doi.org/10.5551/jat.3707
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Also Consider

Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context:

  1. 1A Novel Blood Pressure-independent Arterial Wall Stiffness Parameter; Cardio-Ankle Vascular Index (CAVI)2006 · 952 citations
  2. 2Circadian blood nicotine concentrations during cigarette smoking1982 · 294 citations
  3. 3Cardio-Ankle Vascular Index is a Candidate Predictor of Coronary Atherosclerosis2007 · 270 citations
  4. 4Evaluation of the Cardio-Ankle Vascular Index, a New Indicator of Arterial Stiffness Independent of Blood Pressure, in Obesity and Metabolic Syndrome2008 · 157 citations
  5. 5Beneficial Six-Year Outcome of Smoking Cessation in Older Men and Women with Coronary Artery Disease1988 · 370 citations