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September 25, 2017JNCI Journal of the National Cancer InstituteOpen Access

Chronic Health Conditions and Neurocognitive Function in Aging Survivors of Childhood Cancer: A Report from the Childhood Cancer Survivor Study

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Why the study?

Are cancer treatment exposures and subsequent chronic health conditions associated with impaired neurocognitive function in adult survivors of childhood cancer?

Population

5507 adult survivors of childhood cancer in the Childhood Cancer Survivor Study

Design

Cohort

Follow-up

mean 23.1 years postdiagnosis

Authors

YCYin Ting CheungTBTara M. BrinkmanCLChenghong Li

Discussion

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Member takes

Overview

May warrant neurocognitive monitoring in survivors with chronic conditions; leaves open causal pathways and intervention targets.

Structured PICO

Are cancer treatment exposures and subsequent chronic health conditions associated with impaired neurocognitive function in adult survivors of childhood cancer?

P
Population
5507 adult survivors of childhood cancer (47.1% male; mean [SD] age = 31.8 [7.6] years at evaluation; 23.1 [4.5] years postdiagnosis) in the Childhood Cancer Survivor Study
I
Intervention
Cancer treatment exposures and subsequent chronic health conditions (cardiac, pulmonary, and endocrine)
O
Outcome
Neurocognitive function (task efficiency, memory, emotional regulation) measured via self-reportpatient reported

Non-neurotoxic exposures and subsequent cardiopulmonary and endocrine chronic conditions adversely impact neurocognitive function in aging survivors of childhood cancer.

Cite This Study

Cheung et al. (2017) studied this question.

synapsesocial.com/papers/6a70c0a25671bbf00bc2c39fhttps://doi.org/10.1093/jnci/djx224
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Also Consider

Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context:

  1. 1Neurocognitive Function and CNS Integrity in Adult Survivors of Childhood Hodgkin Lymphoma2012 · 118 citations
  2. 2Chronic Health Conditions in Adult Survivors of Childhood Cancer2006 · 3,647 citations
  3. 3Evaluating Survivors of Pediatric Cancer2005 · 88 citations
  4. 4Physical, Mental, and Neurocognitive Status and Employment Outcomes in the Childhood Cancer Survivor Study Cohort2011 · 116 citations
  5. 5Endocrine and cardiovascular late effects among adult survivors of childhood brain tumors2003 · 372 citations