Doxapram acts as a potent respiratory stimulant and elevates blood pressure via central mechanisms in canine models.
Doxapram's central respiratory and pressor effects in canines; hypothesis-generating and should not yet inform clinical practice.
本論文では呼吸興奮薬であるDoxapramのイヌにおける呼吸および循環作用を検討し以下の成績を得た.1)Doxapram静脈内注入は著明な全身血圧の上昇および速やかな呼吸数増加,呼吸深度の増大を示し,それに伴なう血中ガス分圧の変化(PaO2の上昇,PaCO2の下降)が認められた。2)
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Kubota et al. (1974) studied this question.
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