Why the study?
Does dobutamine affect regional myocardial blood flow and ventricular performance in dogs with acute or chronic myocardial ischemia?
Does dobutamine affect regional myocardial blood flow and ventricular performance in dogs with acute or chronic myocardial ischemia?
Dobutamine acts as a powerful inotrope and increases regional myocardial blood flow, but may exacerbate myocardial damage during acute ischemia.
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May worsen acute ischemia despite flow gains; leaves open net clinical effects in humans.
Willerson et al. (1976) studied this question.
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