Why the study?
Does dobutamine reduce infarction severity and improve cardiac oxygen balance in a canine model of LAD narrowing?
Population
32 male beagles with a narrowed left anterior descending coronary artery
Comparison
Dobutamine vs Isoproterenol or saline
Design
Preclinical
Follow-up
1-3 days
Authors
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May prevent infarction in experimental ischemia; leaves open translation to human acute coronary syndromes.
Does dobutamine reduce infarction severity and improve cardiac oxygen balance in a canine model of LAD narrowing?
In a canine model of coronary narrowing, prompt dobutamine infusion prevented myocardial infarction by improving regional blood flow and oxygen balance without causing excessive chronotropic or vascular effects.
Tuttle et al. (1977) studied this question.
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