May 1, 1978Cardiovascular Research
Comparative haemodynamic and metabolic effects of vasodilator and inotropic agents in experimental myocardial infarction
Why the study?
Does infusion of nitroprusside or dobutamine improve haemodynamic and metabolic parameters compared to saline in an experimental model of myocardial infarction with left ventricular failure?
Population
27 awake dogs following coronary embolisation and onset of left ventricular failure
Comparison
Infusion of nitroprusside or dobutamine vs Infusion of saline (controls)
Design
Preclinical, randomly assigned
Authors
Discussion
Loading...
Member takes
Implication
Supports vasodilator preference for metabolic efficiency in experimental HF; leaves open clinical translation in humans.
Structured PICO
Does infusion of nitroprusside or dobutamine improve haemodynamic and metabolic parameters compared to saline in an experimental model of myocardial infarction with left ventricular failure?
P
Population
27 awake dogs following coronary embolisation and onset of left ventricular failure
I
Intervention
Infusion of nitroprusside or dobutamine
C
Comparator
Infusion of saline (controls)
O
Outcome
Haemodynamic and metabolic effects including cardiac output, left ventricular filling pressure, coronary sinus flow, and myocardial oxygen consumptionsurrogate
In an experimental canine model of myocardial infarction with heart failure, the vasodilator nitroprusside reduced myocardial oxygen consumption while the inotrope dobutamine increased it, suggesting a metabolic advantage for vasodilators.
Cite This Study
Franciosa et al. (1978) studied this question.