Why the study?
Does the addition of isosorbide dinitrate to inotropic therapy improve haemodynamic parameters in patients with acute myocardial infarction and left ventricular failure?
Population
48 consecutive acute myocardial infarction patients with radiographic and haemodynamic left ventricular…
Comparison
Four inotropic agents alone and with subsequent… vs Inotropic agents alone.
Design
Cohort
Follow-up
60 min (acute haemodynamic monitoring)
Authors
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May support adding isosorbide dinitrate to inotropes for further hemodynamic benefit in acute MI with LV failure; hypothesis-generating and should not change practice.
Does the addition of isosorbide dinitrate to inotropic therapy improve haemodynamic parameters in patients with acute myocardial infarction and left ventricular failure?
In acute left ventricular failure complicating myocardial infarction, combining a venodilator with inotropic therapy provides additional haemodynamic benefits by further reducing elevated left heart filling pressure.
Verma et al. (1992) studied this question.
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