Why the study?
Does intravenous sodium nitroprusside compared to dobutamine improve hemodynamics in patients with severe congestive heart failure?
Population
17 patients with severe congestive heart failure due to ischemic heart disease or nonischemic cardiomyopathy
Comparison
Intravenous infusion of sodium nitroprusside vs Intravenous infusion of dobutamine 10…
Design
Cohort
Authors
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Supports agent selection by target hemodynamics in severe HF; leaves open randomized outcome data.
Does intravenous sodium nitroprusside compared to dobutamine improve hemodynamics in patients with severe congestive heart failure?
In severe heart failure, dobutamine and nitroprusside produce comparable increases in cardiac output but have differing effects on arterial pressure, heart rate, and pulmonary wedge pressure, with their combination providing additive hemodynamic benefits.
Mikulic et al. (1977) studied this question.
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