Key result
Dobutamine infusion in dogs with acute myocardial infarction resulted in a smaller infarct size compared to normal saline (10 +/- 1 g vs 15 +/- 2 g).
Why the study?
Does dobutamine infusion improve hemodynamics and reduce infarct size in a canine model of acute myocardial infarction?
Population
19 chronically instrumented conscious dogs with and without acute myocardial infarction
Comparison
Dobutamine 20 microgram/kg per min… vs Normal saline intravenously, once before and…
Design
Preclinical
Authors
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May limit experimental infarct size; leaves open translation to human outcomes or practice.
Does dobutamine infusion improve hemodynamics and reduce infarct size in a canine model of acute myocardial infarction?
Absolute Event Rate: 10% vs 15%
In a canine model of acute myocardial infarction, dobutamine infusion improved hemodynamics and reduced infarct size, suggesting potential utility as an inotropic agent during acute MI.
Liang et al. (1981) studied Acute myocardial infarction (n=19). Dobutamine vs. Normal saline was evaluated on Infarct size. Dobutamine infusion in dogs with acute myocardial infarction resulted in a smaller infarct size compared to normal saline (10 +/- 1 g vs 15 +/- 2 g).
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